Wzrokowe potencjały wywołane wzorcem we wczesnej diagnostyce neuropatii nerwu wzrokowego w przebiegu oftalmopatii Gravesa

The aim of the study: to investigate by means of pattern visual evoked potentials (PVEPs) early neuropathic changes in Graves’ ophthalmopathy (GO) patients without any clinical symptoms of optic neuropathy in order to evaluate the prevalence of subclinical optic neuropathy in GO patients and to elucidate whether there is a relationship between PVEP (P100 and N75 latency), intraocular pressure (IOP) and exophthalmometry. Material and methods. Two groups of patients were examined: 15 patients with GO without clinical signs of dysthyroid optic neuropathy (DON) and 12 healthy controls. The correlations between the N75 and P100 latencies, IOP and Hertel exophthalmometry were investigated. Results. The mean PVEP N75 and P100 latencies were significantly delayed in the GO uncomplicated with DON in comparison with controls (LP100106.2 ± 4.4 ms vs. 102.4 ± ± 2.7 ms, p < 0.01 and LN7579.0 ± 3.7 ms vs. 73.9 ± 2.8 ms, p < 0.001). In GO patients we documented a positive correlation between the LN75 latency and exophthalmometric